TUMOR-COLONIZING E. COLI EXPRESSING BOTH COLLAGENASE AND HYALURONIDASE ENHANCES THERAPEUTIC EFFICACY OF GEMCITABINE IN PANCREATIC CANCER MODELS

Tumor-Colonizing E. coli Expressing Both Collagenase and Hyaluronidase Enhances Therapeutic Efficacy of Gemcitabine in Pancreatic Cancer Models

Desmoplasia is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC) that contributes significantly to treatment resistance.Approaches to enhance drug delivery into fibrotic PDAC tumors continue to be an important unmet need.In this study, we have engineered a tumor-colonizing color touch 7/97 E.coli-based agent that expresses both collagen

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Identifying the morphologic basis for radiomic features in distinguishing different Gleason grades of prostate cancer on MRI: Preliminary findings.

Translation of radiomics into the clinic may require a more comprehensive understanding of the underlying morphologic tissue characteristics they reflect.In the context of prostate cancer (PCa), some studies have correlated gross histological measurements of gland lumen, epithelium, and nuclei with disease appearance on MRI.Quantitative histomorpho

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